Microbial adhesins recognizing extracellular matrix macromolecules

Curr Opin Cell Biol. 1994 Oct;6(5):752-8. doi: 10.1016/0955-0674(94)90104-x.


Microorganisms express a family of cell-surface adhesins that specifically recognize and bind components of the extracellular matrix. Adhesion of microorganisms to host tissues represents a critical phase in the development of many types of infections. Recent studies have focused on the mechanisms of microbial attachment at a molecular level, including the identification of ligand-binding domains in several cell-surface adhesins from Gram-positive bacteria and the construction of adhesin-deficient isogenic mutants.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adhesins, Bacterial / genetics
  • Adhesins, Bacterial / physiology*
  • Amino Acid Sequence
  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Bacterial Infections / drug therapy
  • Bacterial Infections / etiology
  • Cell Adhesion / physiology*
  • Collagen / metabolism
  • Drug Design
  • Extracellular Matrix / physiology*
  • Fibronectins / metabolism
  • Humans
  • Molecular Sequence Data
  • Protein Binding
  • Virulence / physiology


  • Adhesins, Bacterial
  • Anti-Bacterial Agents
  • Fibronectins
  • Collagen