Pharmacokinetics and effects on intracranial pressure of sufentanil in head trauma patients

Br J Clin Pharmacol. 1994 Oct;38(4):369-72. doi: 10.1111/j.1365-2125.1994.tb04368.x.

Abstract

Ten patients with head trauma received an intravenous bolus of sufentanil (2 micrograms kg-1) followed at 30 min by infusion of sufentanil (median 150 micrograms h-1) and midazolam (median 9.0 mg h-1) over 48 h. Median (range) values of pharmacokinetic parameters for sufentanil were: t1/2,z = 16 (7-49) h; CL = 1215 (519-2550) ml min-1; CLR = 7 (2-38) ml min-1; Vss = 10.0 (6.8-24.2) 1 kg-1. Decreases in intracranial pressure (ICP) (from 16.1 +/- 1.7 to 10.8 +/- 1.3 mm Hg; P < 0.05) and mean arterial blood pressure (MAP) (from 85.5 +/- 3.9 to 80.2 +/- 4.9 mm Hg; P < 0.05) were observed within 15 min of the bolus injection of sufentanil and remained unchanged thereafter. Thus, cerebral perfusion pressure (CPP = MAP-ICP) was stable.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Analysis of Variance
  • Blood Pressure / drug effects
  • Child
  • Craniocerebral Trauma / drug therapy*
  • Craniocerebral Trauma / metabolism
  • Craniocerebral Trauma / physiopathology
  • Female
  • Half-Life
  • Humans
  • Injections, Intravenous
  • Intracranial Pressure / drug effects*
  • Male
  • Metabolic Clearance Rate
  • Midazolam / administration & dosage
  • Midazolam / pharmacokinetics
  • Midazolam / pharmacology
  • Midazolam / therapeutic use
  • Middle Aged
  • Radioimmunoassay
  • Regression Analysis
  • Sufentanil / administration & dosage
  • Sufentanil / pharmacokinetics*
  • Sufentanil / pharmacology
  • Sufentanil / therapeutic use

Substances

  • Sufentanil
  • Midazolam