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, 80 (2), 341-52

Dendritic Cell Progenitor Is Transformed by a Conditional v-Rel Estrogen Receptor Fusion Protein v-RelER

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Dendritic Cell Progenitor Is Transformed by a Conditional v-Rel Estrogen Receptor Fusion Protein v-RelER

G Boehmelt et al. Cell.

Abstract

A conditional v-Rel estrogen receptor fusion protein, v-RelER, causes estrogen-dependent but otherwise unaltered v-rel-specific transformation of chicken bone marrow cells. Here, we demonstrate that such v-relER-transformed cells exhibit B lymphoid determinants in line with earlier studies on v-rel-transformed cells. However, following inactivation of v-RelER oncoprotein activity by administration of an estrogen antagonist, cells differentiate into antigen-presenting dendritic cells as judged by several morphological and functional criteria. Additionally, under yet different culture conditions, v-relER cells differentiate into cells resembling polymorphonuclear neutrophils. Our studies therefore suggest that the conditional v-RelER, and probably also the authentic v-Rel, transform a common progenitor for neutrophils and dendritic cells.

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