Characterization of liver lymphomyeloid cells in mice infected with Plasmodium yoelii sporozoites

Immunology. 1994 Aug;82(4):645-50.


We have isolated, characterized and quantified the immunocompetent cells present in the extravascular hepatic compartment at various stages after Plasmodium yoelii malaria infection with sporozoites. Cytological analyses revealed a predominantly lymphoid population. In mice with a primary infection, the predominant cells were CD4+, CD8+ and B lymphocytes. In fully protected mice, CD3+ CD4- CD8- and polymorphonuclear cells, particularly eosinophils, were most common. The significance of changes in subpopulations is discussed in relation to antigen presentation and host-protective mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Separation
  • Eosinophils / immunology
  • Female
  • Flow Cytometry
  • Leukocyte Count
  • Liver / immunology*
  • Lymphocyte Subsets / immunology*
  • Malaria / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Plasmodium yoelii*
  • T-Lymphocyte Subsets / immunology