Erythrocyte and mononuclear blood cell magnesium concentrations are normal in hypomagnesemic patients with chronic renal magnesium wasting

J Am Coll Nutr. 1994 Oct;13(5):463-6. doi: 10.1080/07315724.1994.10718435.

Abstract

Objective: The purpose of this study was to determine the plasma, erythrocyte, and mononuclear blood cell (MBC) magnesium concentrations in patients with chronic, severe hypomagnesemia due to a chronic magnesium-wasting tubulopathy.

Methodology: Six patients with Bartter's syndrome and five patients with magnesium-wasting tubulopathy were compared with normal subjects. We determined magnesium in plasma, erythrocytes, and MBCs.

Results: Patients with chronic magnesium-wasting tubulopathy had a significantly lower plasma magnesium concentration than controls, but erythrocyte magnesium concentration and MBC magnesium concentration and content did not differ significantly between patients and controls.

Conclusion: Two disorders with chronic magnesium-wasting tubulopathies are associated with a low plasma magnesium concentration but normal erythrocyte and MBC magnesium.

MeSH terms

  • Bartter Syndrome / blood
  • Erythrocytes / metabolism*
  • Female
  • Humans
  • Kidney Diseases / blood*
  • Kidney Tubules / metabolism
  • Leukocytes, Mononuclear / metabolism*
  • Magnesium / blood*
  • Magnesium / metabolism
  • Male

Substances

  • Magnesium