Endothelin-A receptors mediate contraction in human cerebral, meningeal and temporal arteries

J Auton Nerv Syst. 1994 Sep;49 Suppl:S117-21. doi: 10.1016/0165-1838(94)90098-1.

Abstract

Endothelin-1 (ET-1), an endothelium-derived vasoconstrictor peptide, produced strong contractions in human cerebral, meningeal and temporal arteries. The isopeptides ET-2 and ET-3 also showed potent constrictor activity; however, ET-3 was less potent. The selective ETA receptor antagonist FR 139317 mediated a shift to the right of the concentration-response curve of ET-1. These results suggest that the powerful constriction elicited by the endothelin-isopeptides in cerebral, meningeal and temporal arteries is mediated through ETA receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azepines / pharmacology
  • Cerebral Arteries / drug effects
  • Endothelin Receptor Antagonists*
  • Endothelins / pharmacology
  • Humans
  • In Vitro Techniques
  • Indoles / pharmacology
  • Meningeal Arteries / drug effects
  • Muscle Contraction / drug effects
  • Muscle, Smooth, Vascular / drug effects*
  • Temporal Arteries / drug effects
  • Vasoconstriction / drug effects*

Substances

  • Azepines
  • Endothelin Receptor Antagonists
  • Endothelins
  • Indoles
  • FR 139317