The effect of age on the penetration of fluorescein into the human eye

J Ocul Pharmacol. 1994 Fall;10(3):521-3. doi: 10.1089/jop.1994.10.521.


The penetration into the eye of fluorescein from a normal drop was found to increase with age and averaged twelve times more in the elderly than in the young. Examination of the literature suggests that this is a result of a greater contact time with the cornea rather than a rise in epithelial permeability.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / physiology*
  • Cell Membrane Permeability
  • Cornea / metabolism
  • Epithelium / metabolism
  • Eye / metabolism*
  • Female
  • Fluorescein
  • Fluoresceins / pharmacokinetics*
  • Humans
  • Male
  • Middle Aged
  • Ophthalmic Solutions


  • Fluoresceins
  • Ophthalmic Solutions
  • Fluorescein