Mucocutaneous reactions to gold: a prospective study of 74 patients with rheumatoid arthritis

J Rheumatol. 1994 Oct;21(10):1814-9.


Objective: To describe causality, morphology, course, and risk factors of mucocutaneous reactions to gold.

Methods: A prospective study of 74 patients with rheumatoid arthritis starting with gold thioglucose.

Results: Thirty-nine patients experienced an episode of gold dermatitis. Sixteen patients continued gold treatment. The estimated treatment withdrawal at 1 year was 26%. The clinical picture was variable and nonspecific. Gold dermatitis was associated with HLA-B35 and disease duration.

Conclusion: Mucocutaneous reactions to gold are nonspecific, therefore a causality assessment is necessary. Incidence is high, but treatment can often be continued with dose reduction and local steroids. The predictive value of risk factors is low.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / epidemiology
  • Aurothioglucose / adverse effects*
  • Aurothioglucose / therapeutic use*
  • Biopsy
  • Drug Eruptions / epidemiology*
  • Drug Eruptions / immunology
  • Drug Eruptions / pathology
  • Female
  • HLA-B35 Antigen / analysis
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prospective Studies
  • Risk Factors
  • Skin / immunology
  • Skin / pathology


  • HLA-B35 Antigen
  • Aurothioglucose