Prevalence of antihuman parvovirus B19 IgG antibodies in patients with refractory rheumatoid arthritis and polyarticular juvenile rheumatoid arthritis

Rheumatol Int. 1994;14(3):87-90. doi: 10.1007/BF00300807.

Abstract

We investigated the prevalence of antihuman parvovirus B19 immunoglobulin G (IgG) antibody in 108 Japanese patients with rheumatoid arthritis (RA) and 11 patients with polyarticular juvenile rheumatoid arthritis (JRA). Seropositivity of anti-B19 was significantly higher in patients with refractory RA (57.6%, 38/66) compared with patients with remittent RA (19.0%, 8/42; P < 0.001) or age-matched controls (24.3%, 19/78; P < 0.001). Patients with refractory polyarticular JRA had a significantly higher frequency of anti-B19 seropositivity (71.4%, 5/7) than age-matched controls (8.3%, 5/60; P < 0.001), while none of the remittent group was positive for the antibody (0/4).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Viral / analysis*
  • Arthritis, Juvenile / immunology*
  • Arthritis, Juvenile / virology
  • Arthritis, Rheumatoid / immunology*
  • Arthritis, Rheumatoid / virology
  • Case-Control Studies
  • Child
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Immunoglobulin G / analysis
  • Male
  • Middle Aged
  • Parvovirus B19, Human / immunology*
  • Prevalence
  • Remission, Spontaneous
  • Serologic Tests

Substances

  • Antibodies, Viral
  • Immunoglobulin G