Effect of long-term consumption of amylose vs amylopectin starch on metabolic variables in human subjects

Am J Clin Nutr. 1995 Feb;61(2):334-40. doi: 10.1093/ajcn/61.2.334.


Long-term consumption of high-amylose starch on insulin and glucose response was investigated in 24 men: 10 control and 14 hyperinsulinemic (HI) subjects. Subjects consumed products made with standard (70% amylopectin, 30% amylose) or high-amylose (70% amylose, 30% amylopectin) cornstarch for two 14-wk periods in a crossover pattern. Starch products replaced usual starches in the self-selected diet for 10 wk followed by 4 wk of a controlled diet. After a starch-tolerance test with bread made from the starch consumed during that period, the insulin response curve area was significantly lower in all subjects after amylose consumption (P < 0.002). Glucose responses in HI and control subjects were similar and did not vary with the type of starch. Fasting triglyceride concentrations were significantly lower in subjects who consumed the high-amylose compared with the standard-starch diet throughout the study. Chronic consumption of high-amylose foods normalized the insulin response of hyperinsulinemic subjects and showed a potential benefit for diabetic subjects.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Amylopectin / administration & dosage
  • Amylopectin / pharmacology*
  • Amylose / administration & dosage
  • Amylose / pharmacology*
  • Blood Glucose / drug effects
  • Dietary Carbohydrates*
  • Fasting / metabolism
  • Humans
  • Hyperinsulinism / blood
  • Insulin / blood
  • Male
  • Middle Aged
  • Triglycerides / blood


  • Blood Glucose
  • Dietary Carbohydrates
  • Insulin
  • Triglycerides
  • Amylose
  • Amylopectin