Interferons in HIV and related diseases

AIDS. 1994 Sep;8 Suppl 3:S19-23. doi: 10.1097/00002030-199409001-00005.

Abstract

Background: Since interferon-alpha has a very broad spectrum of activity it has been investigated in several clinical settings in the HIV-infected population. KAPOSI'S SARCOMA: The rate of response to interferon-alpha is low in patients with low CD4 cell counts, but response rates of over 45% have been achieved in patients with higher counts.

Primary therapy in hiv infection: In 34 asymptomatic patients, the overall percentage of CD4 cells was higher in patients taking interferon-alpha compared to those taking a placebo and the rate of opportunistic infections was lower after a long-term follow-up. A relatively high dose of interferon-alpha was associated with predictable side effects. Lower doses have been used in combination with zidovudine. In a recent trial, 180 patients took either zidovudine alone, interferon-alpha alone or both drugs in combination. So far, the CD4 cell counts have been similar in all treatment groups.

Hepatitis infection: The rate of response shown by hepatitis B infection to interferon-alpha in patients with both hepatitis B and HIV has been reported as less than that in patients without HIV infection. Overall, studies have shown that approximately 37% of patients are cleared of hepatitis B DNA with 3 months of interferon-alpha treatment, compared with a 17% rate of spontaneous clearance. Among hepatitis C patients, 50-75% show a reduction in serum transaminases with 3 months of treatment.

Conclusions: Interferon-alpha is of benefit in some HIV-infected patients, demonstrating efficacy in Kaposi's sarcoma, hepatitis B and hepatitis C.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Review

MeSH terms

  • AIDS-Related Opportunistic Infections / therapy*
  • CD4 Lymphocyte Count
  • Clinical Trials as Topic
  • Combined Modality Therapy
  • HIV Infections / complications
  • HIV Infections / therapy*
  • Hepatitis B / therapy*
  • Humans
  • Randomized Controlled Trials as Topic
  • Sarcoma, Kaposi / etiology
  • Sarcoma, Kaposi / therapy*
  • Zidovudine / therapeutic use

Substances

  • Zidovudine