Abstract
The generation of an effective immune response requires the selection and proliferation of antigen-specific lymphocytes. Activation of at least some T lymphocytes involves the sequential stimulation of cell surface receptors, including the T-cell receptor for antigen, the interleukin 2 receptor, and the prolactin receptor. Prolactin signaling in T lymphocytes appears to utilize a classical receptor-mediated kinase cascade and a novel peptide hormone activation pathway involving nuclear translocation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Antigens / immunology
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Cell Nucleus / metabolism
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Interleukin-2 / physiology*
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Lymphocyte Activation / physiology*
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Models, Biological
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Phosphorylation
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Prolactin / physiology*
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Protein Processing, Post-Translational
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Receptors, Antigen, T-Cell / physiology
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Receptors, Interleukin-2 / physiology
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Receptors, Prolactin / physiology
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Second Messenger Systems*
Substances
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Antigens
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Interleukin-2
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Receptors, Antigen, T-Cell
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Receptors, Interleukin-2
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Receptors, Prolactin
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Prolactin