Marchiafava-Bignami disease: use of contrast media in CT and MRI

Neuroradiology. 1994 Oct;36(7):509-11. doi: 10.1007/BF00593509.


We report two cases of Marchiafava-Bignami disease studied by CT and MRI. Both patients displayed persistent confusion and a disconnection syndrome but had a favourable outcome. In both cases, CT with intravenous contrast medium revealed enhancement of the corpus callosum in the early stage. MRI showed gadolinium uptake in both the genu and splenium of the corpus callosum in one case, 8 days after the onset. Three weeks after admission, cystic lesions appeared in the corpus callosum on MRI T1-weighted sagittal images in both cases. Contrast medium uptake may be useful in the diagnosis of Marchiafava-Bignami disease.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alcoholism / complications
  • Alcoholism / diagnostic imaging*
  • Alcoholism / pathology*
  • Contrast Media*
  • Corpus Callosum / diagnostic imaging
  • Corpus Callosum / pathology
  • Demyelinating Diseases / diagnostic imaging*
  • Demyelinating Diseases / etiology
  • Demyelinating Diseases / pathology*
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Tomography, X-Ray Computed / methods


  • Contrast Media