Prolongation of the prothrombin time after organophosphate poisoning

Pediatr Emerg Care. 1994 Oct;10(5):289-90. doi: 10.1097/00006565-199410000-00012.


Prolongation of the prothrombin time owing to a transient reduction in factor VII activity is described in a 14-month-old child with organophosphate poisoning. Correction after vitamin K administration suggested an organophosphate-related effect on vitamin K-dependent factor VII activity. Historically, coagulation screening has not been routinely recommended after organophosphate intoxications. We suggest, however, that routine screening in such patients may be important. A brief review of organophosphate poisoning and the unique features of our case are presented.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / blood
  • Factor VII
  • Female
  • Humans
  • Infant
  • Organophosphate Poisoning*
  • Poisoning / drug therapy*
  • Prothrombin Time*
  • Vitamin K / therapeutic use*


  • Vitamin K
  • Factor VII
  • Acetylcholinesterase