Allelic loss of the retinoblastoma gene in primary human prostatic adenocarcinomas

Prostate. 1995 Jan;26(1):35-9. doi: 10.1002/pros.2990260108.


Inactivation of the retinoblastoma (Rb) gene has been implicated in the genesis and progression of a number of tumor types, including prostatic adenocarcinomas. We have analyzed a series of 46 surgically-resected human prostatic adenocarcinomas for allelic loss of the Rb gene with PCR amplification of a highly polymorphic region of the gene. 41 of 46 tumors (89%) were informative and 11 of these (27%) had lost one Rb allele. The relative frequency of this occurrence suggests that inactivation of the retinoblastoma gene may be an important event in prostate carcinogenesis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenocarcinoma / genetics*
  • Alleles
  • Base Sequence
  • Gene Deletion*
  • Genes, Retinoblastoma*
  • Humans
  • Male
  • Molecular Sequence Data
  • Prostatic Neoplasms / genetics*