TGF-beta-receptor-mediated signaling

Trends Biochem Sci. 1994 Dec;19(12):548-53. doi: 10.1016/0968-0004(94)90059-0.


Transforming growth factor beta (TGF-beta) and its many relatives are thought to play key roles in the control of cell proliferation and differentiation. In particular, the ability of TGF-beta to induce growth arrest in epithelial cells has drawn considerable attention. The recent cloning of TGF-beta receptors, which are considered to be prototypes of a new class of cell-surface receptors, has provided a first insight into how TGF-beta signaling induces a variety of intracellular changes. Furthermore, recent advances in the characterization of the cell-cycle machinery have stimulated studies aimed at understanding how TGF-beta signaling leads to growth arrest in the late G1 phase of the cell cycle.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Cell Cycle / physiology
  • Cyclins / pharmacology
  • Molecular Sequence Data
  • Protein Kinase Inhibitors
  • Receptors, Transforming Growth Factor beta / chemistry
  • Receptors, Transforming Growth Factor beta / physiology*
  • Signal Transduction / physiology*
  • Transforming Growth Factor beta / pharmacology


  • Cyclins
  • Protein Kinase Inhibitors
  • Receptors, Transforming Growth Factor beta
  • Transforming Growth Factor beta