Idiopathic intracranial hypertension. Lack of histologic evidence for cerebral edema

Arch Neurol. 1995 Feb;52(2):141-5. doi: 10.1001/archneur.1995.00540260045014.


Objective: To study brain histologic features in two cases of idiopathic intracranial hypertension (pseudotumor cerebri) at autopsy.

Design: Formaldehyde solution-fixed sections of cerebral white matter in two cases and structures of the sensory visual system in one case were analyzed.

Setting: University medical center.

Patients: Two patients with idiopathic intracranial hypertension who died unexpectedly.

Main outcome measure: Histologic study of cerebral white matter in the two patients.

Results: We did not find histologic evidence of any type of cerebral edema in our patients. Review of a portion of the material from a previous report is also consistent with this conclusion.

Conclusion: If patients with idiopathic intracranial hypertension have histologically apparent cerebral edema, it is not a consistent finding.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Brain Edema / complications
  • Brain Edema / pathology*
  • Humans
  • Male
  • Pseudotumor Cerebri / complications
  • Pseudotumor Cerebri / pathology*