The tumor-promoting effect of wounding: a possible role for TGF-beta-induced stromal alterations

Crit Rev Oncog. 1994;5(2-3):297-311. doi: 10.1615/critrevoncog.v5.i2-3.90.


From clinical, chemical carcinogenesis and transgenic animal studies, it is evident that wounding has a tumor-promoting effect. We discuss the role of TGF-beta (with special emphasis on TGF-beta 1) in this process and suggest that stromal alterations during wound healing, induced by TGF-beta, can be an important determinant of tumor growth. A tumor and a wound both require similar stromal microenvironments. Thus, a chemically initiated or an oncogene-expressing cell could be complemented to grow into a tumor if it finds itself in a hospitable wound-healing stroma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic / genetics*
  • Cocarcinogenesis*
  • Humans
  • Mice
  • Neoplasms / physiopathology*
  • Transforming Growth Factor beta / genetics
  • Transforming Growth Factor beta / physiology*
  • Wound Healing / physiology*


  • Transforming Growth Factor beta