Rapidly progressive pulmonary alveolar proteinosis in a patient with chronic myelogenous leukemia

Intern Med. 1994 Nov;33(11):710-3. doi: 10.2169/internalmedicine.33.710.


A 46-year-old man with chronic myelogenous leukemia (CML) was admitted to our hospital because of high fever. The chest radiographs showed bilateral groundglass-like infiltrates in the perihilar region. Transbronchial lung biopsy (TBLB) and autopsy revealed PAS-positive granular materials characteristic of pulmonary alveolar proteinosis (PAP). He had received interferon-alpha since the time of CML diagnosis. Busulfan had never been administered. Altered cell-mediated immunity was thought to be closely related to the development of PAP.

Publication types

  • Case Reports

MeSH terms

  • Disease Progression
  • Humans
  • Interferon-alpha / therapeutic use
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy
  • Lung / diagnostic imaging
  • Lung / pathology
  • Male
  • Middle Aged
  • Pulmonary Alveolar Proteinosis / complications*
  • Pulmonary Alveolar Proteinosis / diagnosis
  • Pulmonary Alveolar Proteinosis / immunology
  • Radiography
  • Time Factors


  • Interferon-alpha