The Regulation of Kidney Development: New Insights From an Old Model

Curr Opin Genet Dev. 1994 Oct;4(5):696-702. doi: 10.1016/0959-437x(94)90136-q.

Abstract

The embryonic kidney is an excellent model system in which to address many fundamental issues in developmental biology. Inductive interactions are required for proliferation and differentiation of the ureter epithelium and kidney mesenchyme. Recent studies implicate a receptor-type tyrosine kinase as a target of inductive signals in the developing ureter. In the mesenchyme, the early induction response requires at least two transcription factors, WT1 and Pax-2. Through the integrated application of in vitro culture models and gene targeting methods, the molecular mechanisms underlying kidney morphogenesis are becoming clearer.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / genetics
  • Gene Expression Regulation, Developmental
  • Humans
  • In Vitro Techniques
  • Kidney / embryology
  • Kidney / growth & development*
  • Kidney / metabolism
  • Models, Biological*
  • Nephrons / growth & development
  • PAX2 Transcription Factor
  • Receptor Protein-Tyrosine Kinases / metabolism
  • Signal Transduction
  • Transcription Factors / genetics
  • WT1 Proteins

Substances

  • DNA-Binding Proteins
  • PAX2 Transcription Factor
  • PAX2 protein, human
  • Transcription Factors
  • WT1 Proteins
  • Receptor Protein-Tyrosine Kinases