Influenza virus neuraminidase: structure, antibodies, and inhibitors

Protein Sci. 1994 Oct;3(10):1687-96. doi: 10.1002/pro.5560031007.


The determination of the 3-dimensional structure of the influenza virus neuraminidase in 1983 has served as a platform for understanding interactions between antibodies and protein antigens, for investigating antigenic variation in influenza viruses, and for devising new inhibitors of the enzyme. That work is reviewed here, together with more recent developments that have resulted in one of the inhibitors entering clinical trials as an anti-influenza virus drug.

Publication types

  • Review

MeSH terms

  • Antibodies / immunology*
  • Antigens / chemistry
  • Antigens / immunology
  • Antiviral Agents / chemistry
  • Binding Sites
  • Binding Sites, Antibody
  • Models, Molecular
  • Molecular Structure
  • Neuraminidase / antagonists & inhibitors
  • Neuraminidase / chemistry*
  • Neuraminidase / immunology
  • Orthomyxoviridae / enzymology*


  • Antibodies
  • Antigens
  • Antiviral Agents
  • Neuraminidase