Abstract
Resistance to tetracycline is generally due either to energy-dependent efflux of tetracycline or to protection of the bacterial ribosomes from the action of tetracycline. The genes that encode this resistance are normally acquired via transferable plasmids and/or transposons. Tet determinants have been found in a wide range of Gram-positive and Gram-negative bacteria and have reduced the effectiveness of therapy with tetracycline.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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DNA Transposable Elements
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Gram-Negative Bacteria / drug effects*
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Gram-Negative Bacteria / metabolism
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Gram-Positive Bacteria / drug effects*
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Gram-Positive Bacteria / metabolism
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Plasmids
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Ribosomes / drug effects
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Tetracycline / pharmacokinetics
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Tetracycline / pharmacology*
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Tetracycline Resistance / genetics*
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Tetracycline Resistance / physiology
Substances
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DNA Transposable Elements
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Tetracycline