Epidemiology of tetracycline-resistance determinants

Trends Microbiol. 1994 Oct;2(10):353-7. doi: 10.1016/0966-842x(94)90610-6.


Resistance to tetracycline is generally due either to energy-dependent efflux of tetracycline or to protection of the bacterial ribosomes from the action of tetracycline. The genes that encode this resistance are normally acquired via transferable plasmids and/or transposons. Tet determinants have been found in a wide range of Gram-positive and Gram-negative bacteria and have reduced the effectiveness of therapy with tetracycline.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • DNA Transposable Elements
  • Gram-Negative Bacteria / drug effects*
  • Gram-Negative Bacteria / metabolism
  • Gram-Positive Bacteria / drug effects*
  • Gram-Positive Bacteria / metabolism
  • Plasmids
  • Ribosomes / drug effects
  • Tetracycline / pharmacokinetics
  • Tetracycline / pharmacology*
  • Tetracycline Resistance / genetics*
  • Tetracycline Resistance / physiology


  • DNA Transposable Elements
  • Tetracycline