Origin and molecular epidemiology of penicillin-binding-protein-mediated resistance to beta-lactam antibiotics

Trends Microbiol. 1994 Oct;2(10):361-6. doi: 10.1016/0966-842x(94)90612-2.


Resistance to beta-lactam antibiotics in some naturally transformable bacterial pathogens has arisen by interspecies recombinational events that have generated hybrid penicillin-binding proteins with reduced affinity for the antibiotics. This type of resistance is of particular concern in pneumococci, in which it is increasing worldwide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins*
  • Carrier Proteins / genetics*
  • Clone Cells
  • Gene Transfer Techniques
  • Hexosyltransferases*
  • Muramoylpentapeptide Carboxypeptidase / genetics*
  • Penicillin Resistance / genetics*
  • Penicillin-Binding Proteins
  • Peptidyl Transferases*
  • Pneumococcal Infections / epidemiology
  • Recombination, Genetic
  • Streptococcus pneumoniae / genetics*
  • beta-Lactam Resistance / genetics


  • Bacterial Proteins
  • Carrier Proteins
  • Penicillin-Binding Proteins
  • Peptidyl Transferases
  • Hexosyltransferases
  • Muramoylpentapeptide Carboxypeptidase