[7-D-ALA]-angiotensin-(1-7): selective antagonism of angiotensin-(1-7) in the rat paraventricular nucleus

Brain Res Bull. 1994;35(4):289-91. doi: 10.1016/0361-9230(94)90103-1.

Abstract

Microiontophoretic application of both, the octapeptide angiotensin II (Ang II) and its N-terminal heptapeptide angiotensin-(1-7), [Ang-(1-7)], has been shown to increase the firing rate of rat hypothalamic paraventricular neurones. In the present microiontophoretic study, the effect of the angiotensin analogue [7-D-Ala]-Ang-(1-7) on Ang II- and Ang-(1-7)-induced firing rate increase of paraventricular neurones has been tested. While the response to Ang II was unchanged, the response to Ang-(1-7) was effectively blocked by [7-D-Ala]-Ang-(1-7). The results indicate that the Ang-(1-7)-induced excitation of paraventricular neurones may be mediated by a distinct Ang-(1-7)-receptor and that [7-D-Ala]-Ang-(1-7) is a selective antagonist of this receptor.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects
  • Angiotensin I
  • Angiotensin II / analogs & derivatives*
  • Angiotensin II / antagonists & inhibitors*
  • Angiotensin II / metabolism
  • Angiotensin II / pharmacology
  • Angiotensin Receptor Antagonists*
  • Animals
  • Male
  • Neurons / drug effects*
  • Neurons / physiology
  • Paraventricular Hypothalamic Nucleus / cytology
  • Paraventricular Hypothalamic Nucleus / drug effects*
  • Paraventricular Hypothalamic Nucleus / physiology
  • Peptide Fragments / antagonists & inhibitors*
  • Peptide Fragments / metabolism
  • Peptide Fragments / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Angiotensin / metabolism

Substances

  • 7-Ala-angiotensin (1-7)
  • Angiotensin Receptor Antagonists
  • Peptide Fragments
  • Receptors, Angiotensin
  • Angiotensin II
  • Angiotensin I
  • angiotensin I (1-7)