Chromosomal characteristics of tumorigenic cells derived from a spontaneous uterine leiomyosarcoma of the Chinese hamster

Cancer Genet Cytogenet. 1995 Jan;79(1):54-8. doi: 10.1016/0165-4608(94)00089-t.

Abstract

A tumorigenic cell line (CHAUT) derived from a spontaneous uterine leiomyosarcoma of the Chinese hamster was established, and two clones (CHAUT-C and CHAUT-G) were characterized cytogenetically by both G- and C-band techniques. In both clones, all cells analyzed (53 in the C clone and 65 in the G clone) were distributed within a diploid range (24-26) with a modal number of 25. Their karyotypes were also characterized by four common changes; translocation of heterochromatic segment onto chromosome 2, tetrasomy of chromosome 10, monosomy of X chromosome, and one to three additional marker chromosomes of unknown origin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosome Aberrations*
  • Clone Cells
  • Cricetinae
  • Cricetulus
  • Female
  • Karyotyping
  • Leiomyosarcoma / genetics*
  • Translocation, Genetic
  • Tumor Cells, Cultured
  • Uterine Neoplasms / genetics*