IgG-associated primary glomerulonephritis in children

Clin Nephrol. 1994 Nov;42(5):281-7.


Ten children with IgG-associated primary diffuse mesangial proliferative glomerulonephritis are presented. All cases showed diffuse global IgG deposits in the mesangium. IgG was the sole immunoglobulin deposited in the mesangium in 8 patients and was the predominant immunoglobulin in 2. C3 was also present in 8 patients. Light microscopy revealed variable diffuse and global mesangial proliferation in all cases, with additional focal segmental glomerular sclerosis in one. On electron microscopy, electron-dense deposits in the mesangium were identified in all patients. Clinically, 4 patients presented with the steroid-resistant nephrotic syndrome, and 6 had proteinuria and hematuria. At the latest follow-up, renal function was normal in all patients, 6 showed clinical remission and 4 had slight proteinuria and/or hematuria. These data suggest that there is a clinicopathologic entity, IgG-associated glomerulonephritis, characterized by diffuse mesangial proliferation, predominant mesangial IgG deposition, variable clinical presentation, and a relatively benign course.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Biopsy
  • Child
  • Child, Preschool
  • Complement C3 / analysis
  • Female
  • Follow-Up Studies
  • Glomerular Mesangium / immunology*
  • Glomerulonephritis, Membranoproliferative / epidemiology
  • Glomerulonephritis, Membranoproliferative / immunology*
  • Glomerulonephritis, Membranoproliferative / pathology
  • Humans
  • Immunoglobulin G / analysis*
  • Infant
  • Male
  • Microscopy, Electron
  • Microscopy, Fluorescence
  • Nephrotic Syndrome / drug therapy
  • Nephrotic Syndrome / immunology
  • Prednisolone / therapeutic use
  • Time Factors


  • Complement C3
  • Immunoglobulin G
  • Prednisolone