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, 269 (2), 269-72

Facilitatory Effects of Somatostatin on Reduced Uptake of 2-deoxyglucose in Cerebral Cortical and Hippocampal Slices From Aged Rats

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Facilitatory Effects of Somatostatin on Reduced Uptake of 2-deoxyglucose in Cerebral Cortical and Hippocampal Slices From Aged Rats

S Shibata et al. Eur J Pharmacol.

Abstract

The aim of the present study was to determine whether or not the reduction of 2-deoxyglucose uptake by the cerebral cortical slices in aged rats (22-23 months old) was attenuated by somatostatin or carbachol. In 8-week-old rats, somatostatin and carbachol produced concentration-dependent increases in 2-deoxyglucose uptake. 2-Deoxyglucose uptake of the cortical slices in 22-23-month-old rats was significantly facilitated by treatment with 0.1-1 microM somatostatin or 1-100 microM carbachol. Metabolic responses to somatostatin or carbachol were quite similar in young and aged rats. The present results demonstrated that 2-deoxyglucose uptake by the cerebral cortex was facilitated by somatostatin and carbachol in both young and old rats.

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