High frequency of cancer patients with abnormal assembly of the T cell receptor-CD3 complex in peripheral blood T lymphocytes

Jpn J Cancer Res. 1994 Dec;85(12):1189-92. doi: 10.1111/j.1349-7006.1994.tb02927.x.


Structural abnormality of T cell receptor (TCR)-CD3 complex on the cell surface was investigated in peripheral blood lymphocytes (PBL) from 55 cancer patients. In 24 of the 68 tests done on these patients, the CD3 zeta chain was not detected by immunoprecipitation with anti-CD3 epsilon monoclonal antibody (mAb), but was observed with anti-CD3 zeta mAb, suggesting that a high frequency of cancer patients possesses abnormal T cell receptor (TCR) complex in PBL. On the other hand, the total zeta chain was missing in several advanced cases. During follow-up of several patients, the zeta chain became undetectable after two or three months of cancer progression. It appears that immunosuppressive status can be monitored by analyzing the TCR-CD3 complex on the cell surface of PBL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Disease Progression
  • Female
  • Gastrointestinal Neoplasms / blood
  • Gastrointestinal Neoplasms / immunology
  • Gastrointestinal Neoplasms / pathology
  • Humans
  • Immunologic Surveillance / immunology
  • Male
  • Membrane Proteins / chemistry*
  • Neoplasm Staging
  • Neoplasms / blood
  • Neoplasms / immunology*
  • Neoplasms / pathology
  • Precipitin Tests
  • Receptor-CD3 Complex, Antigen, T-Cell / chemistry*
  • Receptor-CD3 Complex, Antigen, T-Cell / physiology
  • Receptors, Antigen, T-Cell / chemistry*
  • Signal Transduction / physiology
  • Structure-Activity Relationship
  • T-Lymphocytes / immunology


  • Membrane Proteins
  • Receptor-CD3 Complex, Antigen, T-Cell
  • Receptors, Antigen, T-Cell
  • antigen T cell receptor, zeta chain