Multifactorial obstructive sleep apnea in a patient with Chiari malformation

J Neurol Sci. 1994 Nov;126(2):232-6. doi: 10.1016/0022-510x(94)90280-1.


We report a patient with severe obstructive sleep apnea (OSA) associated with a unique combination of syringobulbia-myelia, Chiari malformation type I (CM), absent hypoxic ventilatory drive, vocal cord paralysis, post-menopausal status, obesity, and acute respiratory failure necessitating mechanical ventilation. The remote onset of OSA five years after surgery underscores the need for long-term follow-up of patients with syringobulbia-myelia and CM and the importance of addressing multiple interacting neurologic, metabolic, and mechanical predispositions to sleep-disordered breathing.

Publication types

  • Case Reports

MeSH terms

  • Arnold-Chiari Malformation / complications*
  • Arnold-Chiari Malformation / diagnosis
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Medulla Oblongata / pathology
  • Middle Aged
  • Obesity / complications
  • Postmenopause
  • Respiration Disorders / complications
  • Sleep Apnea Syndromes / complications*
  • Syringomyelia / complications
  • Syringomyelia / diagnosis
  • Syringomyelia / pathology
  • Vocal Cord Paralysis / complications