Bronchoprotective role for endogenous prostaglandin E2

Lancet. 1995 Feb 18;345(8947):436-8. doi: 10.1016/s0140-6736(95)90409-3.


The possibility that impaired production of bronchoprotective factors contributes to the pathogenesis of asthma cannot be excluded. Prostaglandin E2 (PGE2) could be such a factor. It is a dominant cyclo-oxygenase product of airway epithelium and smooth muscle; it has inhibitory effects on inflammatory cells and pathways involved in bronchoconstriction at concentrations known to occur in the airway; inhalation of PGE2 has considerable bronchoprotective effects in patients with asthma; and manoeuvres that increase or decrease endogenous production of PGE2 have beneficial and deleterious effects on airway function.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asthma / physiopathology*
  • Bronchoconstriction / physiology
  • Dinoprostone / physiology*
  • Humans


  • Dinoprostone