Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6

Nature. 1995 Feb 16;373(6515):623-6. doi: 10.1038/373623a0.


The Axl receptor tyrosine kinase was identified as a protein encoded by a transforming gene from primary human myeloid leukaemia cells by DNA-mediated transformation of NIH 3T3 cells. Axl is the founding member of a family of related receptors that includes Eyk, encoded by a chicken proto-oncogene originally described as a retroviral transforming gene, and c-Mer, encoded by a human proto-oncogene expressed in neoplastic B- and T-cell lines. The transforming activity of Axl demonstrates that the receptor can drive cellular proliferation. The function of Axl in non-transformed cells and tissues is unknown, but may involve the stimulation of cell proliferation in response to an appropriate signal, namely a ligand that activates the receptor. We report here the purification of an Axl stimulatory factor, and its identification as the product of growth-arrest-specific gene 6 (ref. 6). This is, to our knowledge, the first description of a ligand for the Axl family of receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Axl Receptor Tyrosine Kinase
  • CHO Cells
  • Cricetinae
  • Cross-Linking Reagents
  • Enzyme Activation
  • Humans
  • Intercellular Signaling Peptides and Proteins*
  • Ligands
  • Molecular Sequence Data
  • Oncogene Proteins / metabolism*
  • Protein Binding
  • Proteins / isolation & purification
  • Proteins / metabolism*
  • Proto-Oncogene Mas
  • Proto-Oncogene Proteins
  • Receptor Protein-Tyrosine Kinases / metabolism*
  • Recombinant Proteins
  • Tumor Cells, Cultured
  • Vitamin K / metabolism


  • Cross-Linking Reagents
  • Intercellular Signaling Peptides and Proteins
  • Ligands
  • MAS1 protein, human
  • Oncogene Proteins
  • Proteins
  • Proto-Oncogene Mas
  • Proto-Oncogene Proteins
  • Recombinant Proteins
  • growth arrest-specific protein 6
  • Vitamin K
  • Receptor Protein-Tyrosine Kinases
  • Axl Receptor Tyrosine Kinase