Bilateral intra-accumbens self-administration of d-amphetamine: antagonism with intra-accumbens SCH-23390 and sulpiride

Psychopharmacology (Berl). 1994 Apr;114(3):477-85. doi: 10.1007/BF02249339.


The efficacy of d-amphetamine to support a selective bilateral intra-accumbens self-administration response was examined. Bilateral intra-accumbens infusions of d-amphetamine were made contingent upon the acquisition of a lever-pressing response. Two identical levers were available within the operant chamber. Depression of the drug lever resulted in the intra-accumbens delivery of 1 microgram d-amphetamine; responses upon the second, control lever were recorded but had no programmed consequences. Animals were not 'primed' with non-contingent infusions of d-amphetamine at any time during these experiments. Nonetheless, animals readily acquired a selective response upon the drug lever. Removal of the d-amphetamine moiety from the infusate resulted in a large decline in responding, and the abolition of the selectivity of the response for the drug lever. Adulteration of the infusate with either the D1 dopamine receptor antagonist SCH-23390 or the D2 dopamine receptor antagonist sulpiride enhanced the rate of response selectively upon the drug lever. Reductions in the dose of d-amphetamine also increased the rate of response. The effect of co-adulteration of the infusate with both SCH-23390 and sulpiride together was purely additive. The implications of these data for the methodology of intracranial drug self-administration, and the relationship between D1 and D2 dopamine receptors within the nucleus accumbens are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzazepines / administration & dosage
  • Benzazepines / pharmacology*
  • Conditioning, Operant / drug effects
  • Dextroamphetamine / administration & dosage
  • Dextroamphetamine / antagonists & inhibitors
  • Dextroamphetamine / pharmacology*
  • Dose-Response Relationship, Drug
  • Injections
  • Male
  • Nucleus Accumbens / anatomy & histology
  • Nucleus Accumbens / physiology*
  • Rats
  • Self Administration
  • Sulpiride / administration & dosage
  • Sulpiride / pharmacology*


  • Benzazepines
  • Sulpiride
  • Dextroamphetamine