Locomotor inhibition by the D3 ligand R-(+)-7-OH-DPAT is independent of changes in dopamine release

J Neural Transm Gen Sect. 1994;95(1):71-4. doi: 10.1007/BF01283032.


The dopamine D3 preferring ligand R-(+)-7-OH-DPAT induced strong hypolocomotion in rats. Doses producing reduction of locomotion failed to affect dopamine release or synthesis rate. These data support the hypothesis that the dopamine D3 receptor is a postsynaptic receptor with an inhibitory influence on rat locomotor activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Chemistry / drug effects
  • Depression, Chemical
  • Dopamine / metabolism*
  • Dopamine Agonists / pharmacology*
  • Dose-Response Relationship, Drug
  • Motor Activity / drug effects*
  • Rats
  • Receptors, Dopamine / drug effects*
  • Receptors, Dopamine / physiology
  • Receptors, Dopamine D2*
  • Receptors, Dopamine D3
  • Tetrahydronaphthalenes / pharmacology*


  • Dopamine Agonists
  • Drd3 protein, rat
  • Receptors, Dopamine
  • Receptors, Dopamine D2
  • Receptors, Dopamine D3
  • Tetrahydronaphthalenes
  • 7-hydroxy-2-N,N-dipropylaminotetralin
  • Dopamine