N- and K-ras oncogenes in plasma cell dyscrasias

Leuk Lymphoma. 1994 Sep;15(1-2):17-20. doi: 10.3109/10428199409051673.


N- and K-ras oncogene mutations represent the most frequent molecular lesions in plasma cell dyscrasias. They are not randomly distributed since they are detectable in multiple myeloma (MM) (9-31%) and plasma cell leukemia (PCL) (30%), and not in monoclonal gammopathy of undetermined significance (MGUS) and solitary plasmacytoma (SP). Codons 12, 13 and 61 of N- and K-ras genes have been found mutated. Mutations affecting codon 61 of N-ras gene are the most frequent finding. A heterogeneous pattern of mutations is described with a prevalence of purine-pyrimidine transversions. Ras gene mutations have been predominantly detected in myelomas characterized by an advanced stage disease, and adverse prognostic parameters. These findings suggest that ras mutations represent a late molecular lesion and may be implicated in tumor progression rather than tumor initiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • DNA Mutational Analysis
  • Genes, ras*
  • Humans
  • Leukemia, Plasma Cell / genetics
  • Monoclonal Gammopathy of Undetermined Significance / genetics
  • Multiple Myeloma / genetics
  • Multiple Myeloma / mortality
  • Paraproteinemias / genetics*
  • Plasmacytoma / genetics
  • Point Mutation
  • Polymorphism, Single-Stranded Conformational
  • Prognosis