Heterogeneity of plasma low-density lipoproteins and atherosclerosis risk

Curr Opin Lipidol. 1994 Oct;5(5):339-49. doi: 10.1097/00041433-199410000-00005.


Increased levels of IDL and small, dense LDL are associated with the risk of coronary artery disease. Possible mechanisms include increased susceptibility of small, dense LDL to oxidation, and to other pathologic effects, such as increased retention in the arterial wall. Beneficial effects of a low-fat diet and certain lipid-lowering therapies on the levels and properties of small, dense LDL or their precursors may contribute substantially to the reductions in coronary atherosclerosis observed in several lipid-lowering trials.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Arteriosclerosis / blood*
  • Arteriosclerosis / drug therapy
  • Arteriosclerosis / epidemiology
  • Arteriosclerosis / therapy
  • Hormones / therapeutic use
  • Humans
  • Hypolipidemic Agents / therapeutic use
  • Lipoproteins, LDL / blood*
  • Phenotype
  • Risk Factors


  • Hormones
  • Hypolipidemic Agents
  • Lipoproteins, LDL