Piracetam-induced improvement of mental performance. A controlled study on normally aging individuals

Acta Psychiatr Scand. 1976 Aug;54(2):150-60. doi: 10.1111/j.1600-0447.1976.tb00107.x.


A double-blind, intra-individual cross-over comparison of the mental performance of 18 aging, non-deteriorated individuals during two 4-week periods of piracetam (1-acetamide-2-pyrrolidone) and placebo administration was performed using conventional and computerized perceptual-motor tasks. In a majority of these tasks the subjects did significantly better when on piracetam than on placebo, a finding consistent with ratings completed by two independent observers. The findings indicate new avenues for the treatment of individuals with reduced mental performance possibly related to disturbed alertness--a neglected group of psychiatric conditions.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Aged
  • Clinical Trials as Topic
  • Drug Evaluation
  • Female
  • Humans
  • Intelligence Tests
  • Learning / drug effects
  • Male
  • Mental Processes / drug effects*
  • Middle Aged
  • Motor Skills / drug effects
  • Perception / drug effects
  • Piracetam / pharmacology*
  • Placebos
  • Psychological Tests
  • Pyrrolidinones / pharmacology*


  • Placebos
  • Pyrrolidinones
  • Piracetam