Hyperlipidemia in pediatric hemodialysis and renal transplant patients. Associated with coronary artery disease

Am J Dis Child. 1976 Sep;130(9):957-61. doi: 10.1001/archpedi.1976.02120100047007.

Abstract

Fasting serum cholesterol and serum triglyceride levels were determined in 15 maintenance hemodialysis (MH) and 35 renal transplant (RT) patients. Fourteen of 15 MH patients (93%) had elevated triglyceride levels (greater than 140 mg/100 ml) compared to 11 of 35 RT recipients (31%) (P less than .001). Two of 15 MH patients (13%) had elevated cholesterol levels (greater than 230 mg/100 ml), compared to 18 of 35 RT recipients (51%) (P = .03). In MH patients, a positive correlation was noted between serum triglyceride levels and carbohydrate intake (P = .03). Autopsy material from 12 children who underwent MH or RT was compared to material from 16 age-matched controls; an increased collagenous content of intima, a possible early indicator of coronary artery disease, was noted more frequently (P less than .006) in index patients compared to controls. Our data demonstrate that hyperlipidemia is a frequent finding in pediatric patients treated with MH and RT, and may be associated with premature coronary artery disease.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Cholesterol / blood
  • Coronary Disease / blood
  • Coronary Disease / etiology*
  • Coronary Disease / pathology
  • Coronary Vessels / pathology
  • Dietary Carbohydrates
  • Female
  • Humans
  • Hyperlipidemias / blood
  • Hyperlipidemias / etiology*
  • Immunosuppression
  • Infant
  • Kidney Transplantation*
  • Male
  • Postoperative Complications*
  • Prednisone / therapeutic use
  • Renal Dialysis / adverse effects*
  • Transplantation, Homologous / adverse effects
  • Triglycerides / blood

Substances

  • Dietary Carbohydrates
  • Triglycerides
  • Cholesterol
  • Prednisone