A review of the microbiology of amoxycillin/clavulanic acid over the 15 year period 1978-1993

J Chemother. 1994 Oct;6(5):283-318. doi: 10.1080/1120009x.1994.11741165.


A review of the published literature over the period 1978-1993 was undertaken to assess any changes in the prevalence of beta-lactamase-producing bacterial pathogens and also any changes in the susceptibility in these pathogens to amoxycillin/clavulanate. The review has involved the examination of over 1500 publications. The review shows that in general there has been an increase in the frequency of beta-lactamase-producing pathogens resistant to ampicillin and amoxycillin but there is no evidence for any significant increase in resistance to amoxycillin/clavulanate over the period of the review.

Publication types

  • Review

MeSH terms

  • Amoxicillin / pharmacology
  • Amoxicillin-Potassium Clavulanate Combination
  • Bacteroides / drug effects
  • Clavulanic Acids / pharmacology
  • Drug Therapy, Combination / pharmacology*
  • Escherichia coli / drug effects
  • Klebsiella / drug effects
  • Microbial Sensitivity Tests
  • Moraxella catarrhalis / drug effects
  • Staphylococcus / drug effects


  • Clavulanic Acids
  • Amoxicillin-Potassium Clavulanate Combination
  • Amoxicillin