Late cranial MRI after cranial irradiation in survivors of childhood cancer

Neuroradiology. 1994 Nov;36(8):652-5. doi: 10.1007/BF00600433.


We carried out MRI on 43 survivors of childhood cancer after different treatment protocols with or without cranial radiotherapy. They were free of disease, therapy having been discontinued 2-20 years earlier. Treatment had been for various malignancies, excluding brain tumours; 27 had received cranial irradiation for acute lymphoblastic leukaemia (ALL) or lymphoma. Two asymptomatic young women treated for ALL had falx meningiomas. White matter changes, low intensity foci (representing calcification or old haemorrhage) and heterogeneous intensity focic old haemorrhages) were seen only in patients who had undergone radiotherapy. Because of the possibility of benign, potentially curable brain tumours occurring after cranial irradiation, it may be wise to carry out occasional cranial imaging in the follow-up of these patients. No routine imaging follow-up is needed after chemotherapy alone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Brain / pathology*
  • Brain / radiation effects*
  • Brain Diseases / diagnosis
  • Brain Diseases / etiology
  • Calcinosis / diagnosis
  • Calcinosis / etiology
  • Cerebral Hemorrhage / diagnosis
  • Cerebral Hemorrhage / etiology
  • Child
  • Combined Modality Therapy
  • Cranial Irradiation* / adverse effects
  • Disease-Free Survival
  • Dura Mater / pathology
  • Female
  • Follow-Up Studies
  • Humans
  • Kidney Neoplasms / radiotherapy
  • Lymphoma / radiotherapy*
  • Magnetic Resonance Imaging*
  • Male
  • Meningioma / diagnosis
  • Neoplasms, Radiation-Induced / diagnosis
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy*
  • Survivors
  • Wilms Tumor / radiotherapy