Benzodiazepine receptor mediation of the anxiolytic-like effect of (-)-nicotine in mice

Pharmacol Biochem Behav. 1994 Nov;49(3):755-7. doi: 10.1016/0091-3057(94)90097-3.

Abstract

The anxiolytic-like effect of (-)-nicotine (1.9 mumol/kg, IP) on the elevated plus-maze in CD1 mice was blocked by the benzodiazepine receptor antagonist flumazenil (1 and 10 mumol/kg, IP). On the other hand, the cholinergic nicotinic channel blocker mecamylamine (1 to 15 mumol/kg, IP), did not affect the anxiolytic-like properties of diazepam in the same test. These data suggest that the reduction in anxiety induced by (-)-nicotine occurs indirectly via the release of endogenous substances that can activate the benzodiazepine receptor.

MeSH terms

  • Animals
  • Anti-Anxiety Agents / antagonists & inhibitors
  • Anti-Anxiety Agents / pharmacology*
  • Behavior, Animal / drug effects
  • Diazepam / pharmacology
  • Flumazenil / pharmacology
  • Male
  • Mecamylamine / pharmacology
  • Mice
  • Nicotine / antagonists & inhibitors
  • Nicotine / pharmacology*
  • Receptors, GABA-A / drug effects*
  • Receptors, Nicotinic / drug effects

Substances

  • Anti-Anxiety Agents
  • Receptors, GABA-A
  • Receptors, Nicotinic
  • Flumazenil
  • Mecamylamine
  • Nicotine
  • Diazepam