Suppressive effects of eugenol and ginger oil on arthritic rats

Pharmacology. 1994 Nov;49(5):314-8. doi: 10.1159/000139248.


This study examined the effect of eugenol and ginger oil on severe chronic adjuvant arthritis in rats. Severe arthritis was induced in the right knee and right paw of male Sprague-Dawley rats by injecting 0.05 ml of a fine suspension of dead Mycobacterium tuberculosis bacilli in liquid paraffin (5 mg/ml). Eugenol (33 mg/kg) and ginger oil (33 mg/kg), given orally for 26 days, caused a significant suppression of both paw and joint swelling. These findings suggest that eugenol and ginger oil have potent antiinflammatory and/or antirheumatic properties.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Arthritis, Experimental / drug therapy*
  • Arthritis, Experimental / etiology
  • Eugenol / therapeutic use*
  • Male
  • Mycobacterium tuberculosis
  • Rats
  • Rats, Sprague-Dawley
  • Spices*


  • Anti-Inflammatory Agents, Non-Steroidal
  • Eugenol