SPECT measurements of cerebral blood volume before and after acetazolamide in occlusive cerebrovascular diseases

Radiat Med. 1994 Sep-Oct;12(5):225-9.


Cerebral blood volume before and after acetazolamide was measured by SPECT to evaluate cerebral vasodilatory capacity in eight patients with cerebrovascular disease and five control subjects. Two SPECT measurements were performed serially, and acetazolamide was administered between them. The ratio of increase in hemispheric blood volume was calculated, and it was compared with the results of cerebral blood flow and cerebral blood volume measurements. A cerebral vasodilatory capacity map, the image after acetazolamide minus the baseline image, was also produced. Acetazolamide increased hemispheric blood volume in all unilateral carotid disease than in the uninvolved hemispheres of the patients and control subjects. The ratio of concordance with blood flow and blood volume measurements was approximated at 80%. Cerebral vasodilatory capacity mapping revealed three defects compatible with the clinical data. SPECT measurements of cerebral blood volume after acetazolamide can be performed following baseline SPECT with no additional radiotracer, and may be helpful to assess hemodynamic status.

Publication types

  • Comparative Study

MeSH terms

  • Acetazolamide / administration & dosage
  • Acetazolamide / pharmacology*
  • Adult
  • Aged
  • Arterial Occlusive Diseases / diagnostic imaging*
  • Arterial Occlusive Diseases / physiopathology*
  • Blood Volume / drug effects*
  • Blood Volume / physiology
  • Carotid Stenosis / diagnostic imaging
  • Carotid Stenosis / physiopathology
  • Cerebrovascular Circulation / drug effects*
  • Cerebrovascular Circulation / physiology
  • Cerebrovascular Disorders / diagnostic imaging*
  • Cerebrovascular Disorders / physiopathology*
  • Child
  • Female
  • Humans
  • Infusions, Intravenous
  • Male
  • Middle Aged
  • Moyamoya Disease / diagnostic imaging
  • Moyamoya Disease / physiopathology
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Technetium Tc 99m Aggregated Albumin / administration & dosage
  • Tomography, Emission-Computed, Single-Photon*
  • Vasodilator Agents / administration & dosage
  • Vasodilator Agents / pharmacology


  • Technetium Tc 99m Aggregated Albumin
  • Vasodilator Agents
  • Acetazolamide