A dysbalanced immune system in cryptogenic Lennox-Gastaut syndrome

Scand J Immunol. 1995 Feb;41(2):209-13. doi: 10.1111/j.1365-3083.1995.tb03555.x.


In children with cryptogenic Lennox-Gastaut syndrome we found a functionally impaired humoral immune response to a primary antigen (haemocyanin), despite signs of a triggered immune system consisting of elevated IgG concentrations. This combination of immunological findings, considered to be the expression of a dysbalanced-triggered as well as functionally impaired-immune system, has also been described in an auto-immune disease like systemic lupus erythaematodes in humans, and in genetically epilepsy-prone rats. The interactions between the immune system and the nervous system in Lennox-Gastaut syndrome will be discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Epilepsy, Absence / immunology*
  • Female
  • Hemocyanins / immunology
  • Humans
  • Immunoglobulin A / blood
  • Immunoglobulin G / blood
  • Immunoglobulin Isotypes / blood*
  • Immunoglobulin M / blood
  • Infant
  • Male
  • Syndrome


  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin Isotypes
  • Immunoglobulin M
  • Hemocyanins