Arthritis after hepatitis B vaccination. Report of three cases

Scand J Rheumatol. 1995;24(1):50-2. doi: 10.3109/03009749509095156.


Side effects of hepatitis vaccination are rare. Only a few cases of arthritis after hepatitis vaccination have been published. We report on three cases of vaccination-induced arthritis with different resulting disease. Two cases show the pattern of reactive arthritis. None of them was associated with HLA-B27. In the third case onset of rheumatoid arthritis was triggered by hepatitis vaccination. These three cases show that arthritis after hepatitis B vaccination probably is more common than reported so far, especially in a genetically predisposed subject (two of our patients expressed HLA-DR4).

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Arthritis, Reactive / complications
  • Arthritis, Reactive / etiology*
  • Arthritis, Reactive / immunology
  • Arthritis, Rheumatoid / complications
  • Arthritis, Rheumatoid / etiology*
  • Arthritis, Rheumatoid / immunology
  • Female
  • HLA-DR4 Antigen / analysis
  • Health Personnel
  • Hepatitis B / prevention & control*
  • Hepatitis B Vaccines / administration & dosage
  • Hepatitis B Vaccines / adverse effects*
  • Humans


  • HLA-DR4 Antigen
  • Hepatitis B Vaccines