Organization of the human serotonin transporter gene

J Neural Transm Gen Sect. 1994;95(2):157-62. doi: 10.1007/BF01276434.


The gene encoding the human serotonin transporter (5-HTT) has been isolated and characterized. The human 5-HTT gene is composed of 14 exons spanning approximately 31 kb. The sequence of all exons including adjacent intronic sequences and a tandem repeat DNA polymorphism (VNTR) has been determined and deposited in the EMBL/GenBank data base with the accession numbers X76753 to X76762. The characterization of 5-HTT gene will aid to advance molecular pharmacologic studies of 5-HT uptake regulation and facilitate investigations of its role in psychiatric disorders.

MeSH terms

  • Base Sequence
  • Carrier Proteins / genetics*
  • DNA, Complementary / genetics
  • Exons
  • Genes*
  • Humans
  • Introns
  • Membrane Glycoproteins / genetics*
  • Membrane Transport Proteins*
  • Mental Disorders / genetics
  • Minisatellite Repeats
  • Molecular Sequence Data
  • Nerve Tissue Proteins / genetics*
  • Serotonin / metabolism
  • Serotonin Plasma Membrane Transport Proteins


  • Carrier Proteins
  • DNA, Complementary
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • SLC6A4 protein, human
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin

Associated data

  • GENBANK/X76753
  • GENBANK/X76762