Pathophysiology of left ventricular hypertrophy in dialysis patients

Blood Purif. 1994;12(4-5):277-83. doi: 10.1159/000170174.


Left ventricular hypertrophy is a frequent cardiovascular alteration in end-stage renal disease patients on hemodialysis which is associated with increased morbidity and mortality. Hypertrophy results from chronic flow and pressure overload and from poorly understood neurohumoral alterations. Clinical symptomatology associated with ventricular hypertrophy is related to diastolic dysfunction which characterizes this condition. The symptoms are (1) an unusual sensitivity to volume changes such that hypotension and hemodynamic instability and/or pulmonary edema occur with small volume variations and (2) a high frequency of supraventricular arrhythmias.

Publication types

  • Review

MeSH terms

  • Anemia / complications
  • Blood Volume
  • Hemodynamics
  • Humans
  • Hypertension / complications
  • Hypertrophy, Left Ventricular / etiology
  • Hypertrophy, Left Ventricular / physiopathology*
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / physiopathology*
  • Kidney Failure, Chronic / therapy
  • Myocardium / pathology
  • Renal Dialysis* / adverse effects
  • Ventricular Function, Left