Abstract
The results on thimerosal (Merthiolate) hypersensitivity of a retrospective study, together with the relevant data on thimerosal hypersensitivity referred to in the literature up to 1993, are presented. Positive patch test reactions to thimerosal (0.1% pet.) were observed in 32 (1.3%) of 2461 adult patients with suspected contact allergy examined in the period 1987-1992. 20 (0.8%) patients had a solitary positive patch test to thimerosal. The observed incidence is low. Clinical symptoms related to thimerosal hypersensitivity were observed in only 3 patients. The collected results are discussed with emphasis on the clinical implications of sensitization to thimerosal. It appears that a positive patch test to thimerosal is frequently clinically irrelevant.
MeSH terms
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Adult
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Ammonia / adverse effects
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Balsams / adverse effects
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Dermatitis, Contact / epidemiology*
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Ethylenediamines / adverse effects
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Eugenol / adverse effects
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Eugenol / analogs & derivatives
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Female
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Humans
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Hypersensitivity / epidemiology*
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Hypersensitivity, Delayed / etiology
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Incidence
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Irritants / adverse effects
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Male
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Mercuric Chloride / adverse effects
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Middle Aged
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Netherlands / epidemiology
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Nickel / adverse effects
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Patch Tests
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Perfume / adverse effects
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Phenylmercury Compounds / adverse effects
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Retrospective Studies
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Thimerosal / adverse effects*
Substances
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Balsams
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Ethylenediamines
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Irritants
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Perfume
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Phenylmercury Compounds
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Thimerosal
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Eugenol
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nickel sulfate
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Mercuric Chloride
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isoeugenol
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ethylenediamine
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Ammonia
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Nickel
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Peruvian balsam
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mercuric chloride, ammoniated
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phenylmercuric nitrate, basic