Potent glycogenic effect of GLP-1(7-36)amide in rat skeletal muscle

Diabetologia. 1994 Nov;37(11):1163-6. doi: 10.1007/BF00418382.


GLP-1(7-36)amide is an intestinal post-translational proglucagon product released mainly after carbohydrate ingestion, the glucose dependent insulinotropic and antidiabetogenic actions of which have been documented. In this work, by exploring whether GLP-1(7-36)amide has any effect on the glucose metabolism of the muscle, we have observed that this peptide, at physiological concentrations, exerts in this tissue an increment of the D-[U-14C]glucose incorporated into glycogen, which is accompanied by an increase in the glycogen synthase a activity; also, it stimulates both glucose oxidation and lactate formation. These data indicate that the skeletal muscle is one of the target tissues for GLP-1(7-36)amide, where its insulin-like effect explains, at least in part, its plasma glucose lowering action; thus, GLP-1(7-36)amide may well be implicated in the physiological control of glucose homeostasis after meals, not only by acting as an incretin, but also by directly promoting glucose disposal.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Glucagon / pharmacology
  • Glucagon-Like Peptide 1
  • Glucagon-Like Peptides
  • Glucose / metabolism*
  • Glycogen / metabolism
  • Glycogen Synthase / metabolism
  • Insulin / pharmacology
  • Lactates / metabolism
  • Lactic Acid
  • Muscle, Skeletal / drug effects*
  • Muscle, Skeletal / metabolism
  • Neurotransmitter Agents / pharmacology*
  • Peptide Fragments / pharmacology*
  • Phosphorylase a / metabolism
  • Rats
  • Rats, Wistar


  • Insulin
  • Lactates
  • Neurotransmitter Agents
  • Peptide Fragments
  • glucagon-like peptide 1 (7-36)amide
  • Lactic Acid
  • Glucagon-Like Peptides
  • Glucagon-Like Peptide 1
  • Glycogen
  • Glucagon
  • Phosphorylase a
  • Glycogen Synthase
  • Glucose