Localization of the human soluble epoxide hydrolase gene (EPHX2) to chromosomal region 8p21-p12

Hum Genet. 1995 Mar;95(3):356-8. doi: 10.1007/BF00225209.

Abstract

Epoxide hydrolases have an important function in organisms in that they catalyze the transformation of potentially toxic or carcinogenic epoxides into the corresponding diols. In this study, the chromosomal localization was determined for the human gene encoding soluble epoxide hydrolase. A polymerase chain reaction fragment corresponding to the C-terminal region of the mouse protein was used to isolate a cosmid clone from a human genomic library. By fluorescence in situ hybridization to metaphase chromosomes, the soluble epoxide hydrolase gene was then localized to chromosomal region 8p21-p12.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Blotting, Southern
  • Chromosomes, Human, Pair 8*
  • DNA Primers
  • DNA Probes
  • Epoxide Hydrolases / genetics*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Mice
  • Molecular Sequence Data

Substances

  • DNA Primers
  • DNA Probes
  • Epoxide Hydrolases